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Patients with angle closure have increased iris thickness, curvature and area
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BOSTON — Increased iris thickness, curvature and area are risk factors for angle closure even after adjusting for other known ocular risk factors, according to a study.
In the community-based, cross-sectional, observational study presented at the World Glaucoma Congress here, 2,047 patients older than 50 years of age without ophthalmic symptoms were recruited from a community clinic in Singapore. All patients underwent gonioscopy and anterior segment optical coherence tomography. Angle closure was defined as the presence of at least 180° of angle in which the posterior pigmented trabecular meshwork was not visible on gonioscopy in primary position.
Norlina Ramli, MD, said of the 1,465 eyes available for analysis, 315 patients (21.5%) had angle closure. Mean curvature and iris thickness were greater in the patients with angle closure.
"Anatomical variations in iris parameters — curvature, thickness and area — independent of anterior chamber depth and axial length are associated with narrow angles. These associations are particularly stronger in women and older people 60 years of age and older," she said.