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Partial CNV detachment may result from PDT, TTT
NAHARIYA, Israel — Partial detachment of choroidal neovascularization can occur after photodynamic therapy and transpupillary thermotherapy, according to clinicians here.
The detachment may possibly be a favorable outcome of these therapies, the clinicians said.
Shimon Rumelt, MD, and colleagues here at Western Galilee-Nahariya Medical Center reviewed the features of CNV detachment in two patients with CNV due to age-related macular degeneration. One patient out of 300 with AMD treated by photodynamic therapy developed partial CNV detachment and folding 6 weeks after the second PDT treatment. One patient out of 100 with AMD treated by transpupillary thermotherapy developed partial CNV detachment and folding 6 weeks after the second TTT treatment.
The CNVs were large and located between the retina and retinal pigment epithelium. The best corrected visual acuity improved in one patient from 20/80 to 20/40 and in the other patient from counting fingers at 6 feet to 20/200 after the CNV treatment.
The low energy and selectivity of PDT and TTT may explain this phenomenon, the authors believe.
The study is published in the December issue of American Journal of Ophthalmology.