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Orally administrated moxifloxacin achieves therapeutic levels
Orally administered moxifloxacin reaches therapeutic levels in the noninflamed eye while maintaining good tolerability, researchers found.
Gaurav K. Shah, MD, and colleagues, looked at the intraocular penetration of moxifloxacin hydrochloride. They concluded that because of the drug’s additional broad spectrum coverage, low minimal inhibitory concentration against 90% levels and excellent bioavailability, newer-generation fluoroquinolones are effective in managing segment infections.
The prospective study looked at 15 patients scheduled for vitrectomy between September and November 2004 at the Barnes Retina Institute in St. Louis. Samples of aqueous, vitreous and serum were analyzed after oral administration of two tablets containing 400 mg of moxifloxacin.
“Orally administered moxifloxacin achieves therapeutic aqueous and vitreous levels in the noninflammed human eye and the activity spectrum appears to encompass appropriately the most frequently encountered bacterial species involved in endophthalmitis,” Dr. Shah and colleagues said.
The article was published in the February issue of Archives of Ophthalmology.