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Oral moxifloxacin reached ‘early significant levels’ in anterior chamber, study finds
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Moxifloxacin penetrated into the anterior chamber of uninflamed human eyes at significant levels early after oral administration and maintained those levels for at least 12 hours, according to a study.
G. Kampougeris and colleagues studied the pharmacokinetics of orally administered moxifloxacin in 35 patients undergoing cataract surgery. All patients received two doses of 400 mg of moxifloxacin 12 hours apart. Patients were divided into six groups and moxifloxacin levels in aqueous humor and serum were measured at six intervals up to 12 hours after the administration of the second dose.
Mean levels of moxifloxacin in the anterior chamber were 1.2 µg/ml in the 2-hour group, reached 1.58 µg/ml in the 8-hour group and declined to 1.23 µg/ml in the 12-hour group. The mean ratio of aqueous to serum moxifloxacin level was 38%.
The study is published in the May issue of British Journal of Ophthalmology.