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Optic disc change measured longitudinally could be effective endpoint for glaucoma studies

Ophthalmology. 2009;116(11):2110-2118.

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Prior disc or field changes were predicators for field progression over time, a study found, rendering the measurements a possible endpoint for future glaucoma study.

"Longitudinally measured optic disc change is predictive of subsequent visual field progression and may be an efficacious endpoint for functional outcomes in clinical studies and trials in glaucoma," the study authors said.

The prospective, longitudinal, cohort study examined 81 open-angle glaucoma patients who underwent confocal scanning laser tomography and standard automated perimetry at 6-month intervals.

Total median follow-up in the study was 22 examinations over 11 years.

According to the study, patients with prior disc change had a shorter mean time to field progression. Those with prior field change had "statistically earlier subsequent field progression." Cases with either field change or disc change had worse rates of mean deviation change.

"Patients with subsequent field progression were up to three times more likely to have prior disc change compared with those without, and up to five times more likely to have prior field change compared with those without," the authors said.