Ophthotech initiates phase 1 trial of anti-C5 aptamer for treating AMD
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PRINCETON, N.J. Ophthotech has enrolled the first patient in a phase 1 clinical trial of ARC1905, an anti-C5 complement factor aptamer being developed to treat age-related macular degeneration, the company announced in a press release.
The study will evaluate the safety and tolerability of ARC1905 in combination with an anti-VEGF agent, the release said.
"Preclinical and human genetic linkage studies strongly support the significant role of complement-mediated inflammation in both dry and wet AMD," Samir Patel, MD, president and chief executive officer of Ophthotech, said in the release. "We believe that anti-C5 aptamer blockade represents a potential breakthrough therapy for both wet and dry forms of AMD."
ARC1905 is the second of three compounds the others are E10030 and volociximab (M200) that Ophthotech is developing to treat AMD.