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ONTT releases 10-year data

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Patients with acute optic neuritis who have one or more brain lesions on baseline MRI have a more than 50% chance of progressing to multiple sclerosis over a period of 10 years, according to long-term results of a major study. The Optic Neuritis Study Group found that higher numbers of lesions do not seem to affect the risk of progression.

Researchers in the Optic Neuritis Treatment Trial study group followed 388 patients who experienced acute optic neuritis between 1988 and 1991. Patients were followed for 10 to 13 years to determine the likelihood of developing multiple sclerosis.

The overall 10-year risk for developing multiple sclerosis for patients in the study was 38%. In the 160 patients who had one or more typical lesions on baseline MRI, the risk of developing MS was 56%; in those without lesions the risk was 22%.

The study is published in the July issue of Archives of Ophthalmology.