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OCT pinpoints retinal nerve fiber layer atrophy in glaucomatous eyes
Invest Ophthalmol Vis Sci. 2009;50(2):662-668.
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Optical coherence tomography detected progressive glaucomatous retinal nerve fiber layer atrophy in eyes showing localized progressive loss of retinal nerve fibers in red-free photographs.
Repeated testing enhanced the specificity of the Stratus OCT (Carl Zeiss Meditec) imaging, the study authors said.
The study included 27 eyes of 27 patients who showed progressive retinal nerve fiber layer atrophy; a control group comprised 62 patients. Test-retest variability of each clock hour, quadrant and average retinal nerve fiber layer thickness was established in another control group of 53 patients. The 27 patients showing progressive retinal nerve fiber layer atrophy had a mean age of 53.3 years.
Study data showed sensitivity of OCT retinal nerve fiber layer measurement, ranging from 14.8% for average thickness to 85.2% for clock hour thickness when tested at a 95% confidence level. Specificity of measurement was about 95% for average retinal nerve fiber layer thickness, 59.7% for clock hour thickness and 77.4% for quadrant thickness.
Based on two consecutive re-examinations, specificity rose to 86.6% for clock hour measurement and 92.5% for quadrant thickness measurement.