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Non-keratoconic steep corneas observed in patients with posterior polymorphous corneal dystrophy
Cornea. 2011;30(10):1120-1124.
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Steep corneal curvatures without evidence of keratoconus may be observed in patients with posterior polymorphous corneal dystrophy, a case series found.
A retrospective, descriptive, nonrandomized study discovered 35 eyes of 18 patients with this criteria. The authors accumulated a cohort of patients who presented between 1982 and 2004 with a mean topographic simulated keratometry reading of 52.21 D, ranging from 46.47 D to 59.86 D (standard deviation: 3.69 D), with no slit lamp or topographic findings suggestive of keratoconus.
All patients manifested diffuse thickening of Descemet's membrane with numerous interspersed vesicular opacities or diffusely hazy corneas with stromal thickening and opacification.
None of the patients' affected family members had an average keratometry reading of less than 46.47 D, implying that patients with posterior polymorphous corneal dystrophy and steep non-keratoconic corneas have a common genetic mutation differing from that of their counterparts with non-steep non-keratoconic corneas, the study authors said.