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No link between glaucoma, Helicobacter pylori infection or CagA-bearing strains of the virus, study suggests

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Neither Helicobacter pylori infection nor seropositivity for H. pylori strains bearing the virulent cytotoxin-associated gene A product appears to contribute significantly to the pathogenesis of glaucoma of any type, a prospective study by researchers in Israel suggests.

Michael Regenbogen, MD, and colleagues at Tel Aviv University evaluated seropositivity to H. pylori and to its cytotoxin-associated gene A (CagA) product in 51 patients with various types of glaucoma and compared results with a control group of 36 cataract patients.

The investigators detected H. pylori infection and CagA seropositivity in 31 (60.8%) and 26 (51%) of glaucoma patients, respectively. In addition, they detected H. pylori infection and CagA seropositivity in 22 (61.1%) and 19 (52%) of control patients, respectively, according to the study.

"Similar rates of H. pylori infection and CagA-positive strain were found in all glaucoma subgroups, and none of them was statistically different from those of controls," the study authors said.

The study is published in the April/May issue of Journal of Glaucoma.