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New surface modification may reduce endophthalmitis-causing bacteria on IOLs
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Surface modification with Dynasilan, a fluoroalkylsilane, reduced the adherence of common endophthalmitis-causing bacteria on several IOL materials in an in vitro pilot study.
Hans Hoerauf, MD, of the University Eye Clinic Lübeck, in Lübeck, Germany, and colleagues evaluated the effect of Dynasilan on bacterial adherence when applied to PMMA, silicone and hydrogel IOLs. The researchers incubated Dynasilan-coated IOLs and unmodified control IOLs in brain-heart infusion broth with either Staphylococcus epidermidis or Propionibacterium acnes.
After incubation of the lenses, the researchers found a lower number of S. epidermis and P. acnes bacteria on Dynasilan-treated IOLs than on the unmodified control lenses.
Dynasilan reduced bacterial adherence on all IOL materials tested, the study authors said. Further studies must examine the stability and biocompatibility of Dynasilan, they added.
The study is published in the September issue of Graefe's Archive for Clinical and Experimental Ophthalmology.