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Nerve fiber layer measurements decrease with increasing refractive error

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Retinal nerve fiber layer measurement values decreased with increasing myopia and hyperopia in a study using scanning laser polarimetry. In clinical practice, the study authors recommend, reduced retinal nerve fiber layer thickness values should be viewed “with the necessary caution, and additional polarimetric signs for glaucomatous damage should be taken into consideration.”

Stephan Kremmer and colleagues at the University of Essen, Germany, studied 75 eyes with myopia ranging from –0.75 D to –8.5 D, 24 eyes with hyperopia from 0.75 D to +6.5 D and 40 emmetropic eyes. Scanning laser polarimetry readings were compared.

There were highly significant reductions in average thickness, ellipse average, superior average, inferior average and superior integral in both myopic and hyperopic eyes compared with the emmetropic eyes. No significant differences were seen between the myopic and the hyperopic eyes.

The study is published in the June issue of Graefe’s Archive for Clinical and Experimental Ophthalmology.