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Mushroom keratoplasty may restore vision in patients with central corneal scars
Am J Ophthalmol. 2012;153(1):44-50.
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Microkeratome-assisted mushroom keratoplasty restored vision in patients who had full-thickness, central corneal scarring from previous infection, according to a study.
"Visual and refractive results of mushroom keratoplasty compare favorably with those of conventional penetrating keratoplasty," the researchers said.
The prospective, noncomparative, interventional cases series evaluated the visual outcomes and graft survival rates in 31 patients undergoing microkeratome-assisted mushroom-shaped keratoplasty between January 2004 and December 2006. All patients had central vascularized full-thickness leukoma resulting from infectious keratitis, originating from herpes simplex virus in 16 patients, bacterial infection in 10 patients, and Acanthamoeba infection in five patients.
Results showed that best corrected visual acuity was 20/40 or better, with a refractive astigmatism of 4.5 D or less, in 26 patients at 3 years postop. Endothelial cell count at 3 years averaged 1,584 cells/mm², with a mean 40.7% cell loss compared to the preop value. The graft survival rate at 3 years was 90.3%, and 96.7% when nonimmunologic causes for graft failure were excluded.