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Model may help predict effectiveness of ROP treatment

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A computerized risk model may be useful for identifying patients who are more likely to have positive outcomes following treatment for prethreshold retinopathy of prematurity, according to a study.

To identify patients who could be included in the Early Treatment for Retinopathy of Prematurity (ROP) trial, Robert J. Hardy, PhD, and colleagues analyzed data from one eye each of 613 infants included in the natural history group of the multicenter Cryotherapy for ROP trial. Only infants who had one or both eyes progress to prethreshold ROP were included, and the course of ROP was tracked in only one eye over a 3 month period.

The researchers divided the eyes into 10 categories based on predicted outcome, which then allowed eyes to be divided into two groups, high-risk and low-risk.

Of the high-risk eyes, 36% had an unfavorable outcome 3 months post-term compared to 5% of low-risk eyes.

The study is published in the December issue of Archives of Ophthalmology.