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Microaneurysm rate may be predictor of diabetic retinopathy progression

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FORT LAUDERDALE, Fla. — A retrospective study has shown that a novel "MA Tracker" of microaneurysms in color fundus photographs may be able to predict progression in diabetic retinopathy to clinically significant macular edema.

José Cunha-Vaz, MD, and colleagues presented a retrospective 10-year analysis on 113 eyes of 113 patients in Coimbra, Portugal, in a poster here at the Association for Research in Vision and Ophthalmology meeting.

In the 10-year follow up period, 17 patients developed clinically significant macular edema (CSME) and 96 did not, according to data in the poster.

The MA Tracker produced a 70.6% sensitivity rate and a 91.7% specificity for development of CSME requiring photocoagulation.

"A high [microaneurysm] formation rate earmarked on color fundus photographs appears to be a good predictor of [diabetic retinopathy] progression to CSME in type 2 diabetic patients with nonproliferative retinopathy," Dr. Cunha-Vaz and colleagues said in the poster.