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Methotrexate can be alternative to steroids for ocular inflammation
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Patients with uveitis or scleritis may benefit from methotrexate treatment, either as an adjunct to or replacement of systemic corticosteroids, according to a study.
Audrey Kaplan-Messas and colleagues at the Goldshleger Eye Institute in Israel retrospectively reviewed the efficacy of methotrexate in 39 patients with uveitis or scleritis. All were treated with methotrexate following inadequate control with corticosteroids. Mean age was 26.6 years; mean follow up was 21.5 months.
Ten patients discontinued therapy because of side effects. Full or partial control of inflammation was achieved in 23 of the remaining 29 patients. Treatment response was noted after a mean of 2.4 months. Ten patients were fully controlled and discontinued methotrexate therapy after a mean of 20.9 months.
The study is published in Ocular Immunology and Inflammation.