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Measurements of RNFL using spectral-domain OCT show positive reproducibility

Eur J Ophthalmol. 2011;21(3):264-270.

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Retinal nerve fiber layer measurements using spectral-domain optical coherence tomography produced promising reproducibility results with low intra-session, inter-session and inter-examiner variability, a study found.

The study included 32 eyes of 32 healthy individuals used as controls and 34 eyes of 34 patients with chronic glaucoma. All eyes were tested using RNFL measurements with the Cirrus HD-OCT Model 4000 (Carl Zeiss Meditec).

Few reports have investigated reproducibility of results for the Cirrus HD-OCT, the study authors said.

Each selected eye was tested five times in one sitting by one examiner to assess intra-session variability. Each eye was again tested by the same examiner on five different days to collect the inter-session variability. The tests were performed again by a different examiner to determine the inter-examiner variability.

"In the present study, we found high [intra-class correlation coefficients] and low [coefficients of variation] values for intra-session, inter-session and inter-examiner analyses, which suggests an excellent reproducibility with the Cirrus OCT," the study authors said.