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Loss of central corneal thickness during cross-linking does not lead to complications

Ophthalmology. 2009;116(12):2336-2339.

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Corneal cross-linking produces a significant decrease in central corneal thickness, but that fact may not portend complications related to the treatment.

According to a study of 15 eyes, mean preoperative central corneal thickness decreased from 458 µm preoperatively to a mean 415.7 µm after removal of the epithelium, which is done to provide access to the corneal stroma.

Mean central corneal thickness was further reduced to 340.7 µm at the end of riboflavin solution instillation. But "there was no statistically significant difference between riboflavin instillation and any interval during the 30-minute [ultraviolet A] irradiation," the study authors said.

During the course of the study, however, there were no complications related to the procedure noted. There was no statistically significant difference in preoperative vs. 1-month postoperative endothelial cell counts.