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IOP, optic disc changes correlate in glaucoma suspects

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Intraocular pressure levels seem to correlate with topographic changes in the optic disc in eyes of patients with suspected high-tension glaucoma, according to a study. The authors said an IOP of less than 18 mm Hg is a safe target for these patients to delay topographic optic disc changes.

Masaki Tanito, MD, and colleagues at Senshokai Eye Institute in Kyoto, Japan, studied IOP and optic disc changes in 48 eyes of high-tension glaucoma suspects. Follow-up was at least 2.5 years, with a mean of 4.4 years, and IOP was measured every 3 months.

The percentage of time the eyes had IOP controlled under 22 mm Hg was significantly correlated with changes in neuroretinal rim area and in cup-to-disc ratio using linear regression analysis. Length of follow-up did not affect the significance of the findings. No significant correlation was found for eyes with IOPs less than 18 mm Hg and changes in disc parameters.

The authors recommended setting a target IOP between 18 and 21 mm Hg for these patients.

The study is published in Ophthalmology.