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Ionic contact lens could be used for ocular drug delivery
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Zwitter ionic soft contact lenses could potentially be used to deliver an ophthalmic drug while being worn, a study suggests.
Masumi Kanemoto, MD, and colleagues evaluated levels of drug uptake, measured using chlorpheniramine maleate and sodium cromoglycate, between two types of nonionic soft contact lens, an anionic soft contact lens and a zwitter ionic soft contact lens.
They found that the anionic soft contact lens resulted in the largest drug uptake and was accompanied by dimensional changes. The nonionic and zwitter ionic soft contact lens had lower drug uptakes and dimensional stability, according to the study.
The zwitter ionic soft contact lens also allowed cell permeability comparable to oral administration, the authors noted.
The study was published in the July issue of Eye & Contact Lens.