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Intravitreal triamcinolone may influence vitreomacular changes in DME patients
Retina. 2008;28(10):1435-1442.
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Prevalence of perifoveal detachment may be higher after intravitreal triamcinolone compared with macular grid laser photocoagulation in patients with diabetic macular edema.
Patients with perifoveal detachment with traction after triamcinolone had worse visual outcomes and increased central macular thickness when compared with patients who had a perifoveal detachment after macular grid laser photocoagulation. There was no difference in visual outcomes when patients with perifoveal detachment were excluded.
The vitreomacular relationship on serial optical coherence tomography imagers were analyzed to determine whether the treatment modalities might affect posterior vitreous detachment and whether the effect might explain patients who do not respond to laser photocoagulation treatment, as noted in studies such as the Early Treatment Diabetic Retinopathy Study.
The results show that changes in vitreomacular relationship affect the outcome of treatment with intravitreal triamcinolone for diabetic macular edema. The study suggested that this influence may be more pronounced among patients treated with triamcinolone compared with patients treated with laser photocoagulation.