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Intraoperative floppy iris syndrome not linked to pseudoexfoliation, diabetes mellitus, hypertension

Ophthalmic Surg Lasers Imaging. 2009;40(3):232-238.

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While intraoperative floppy iris syndrome was significantly associated with alpha-1 adrenergic blocker use and male gender, it had no association with pseudoexfoliation, diabetes mellitus and hypertension, a study found.

"Intraoperative floppy iris syndrome was observed in 2.8% of patients and was strongly related to [alpha-1 adrenergic blocker] use, particularly in smaller pupil diameters," the study authors said.

The prospective study looked at 500 cataract patients for adverse events intraoperatively, including pupillary constriction, iris billowing and iris prolapse from the wound. Multinomial regression analysis was used to examine the relationship between intraoperative floppy iris syndrome and various factors.

The researchers found that pupil constriction was significantly associated with pseudoexfoliation (P < .001), hypertension (P = .021) and diabetes mellitus (P = .005). Iris billowing was also associated with diabetes mellitus (P = .003). However, these conditions were not associated with intraoperative floppy iris syndrome.