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Intracameral triamcinolone, prednisolone eye drops similarly effective for inflammation after phaco
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Injecting 1 mg of intracameral triamcinolone acetonide after uncomplicated phacoemulsification cataract surgery appears to control postoperative inflammation as well as daily regimens of topical prednisolone acetate, according to a study by researchers in Turkey.
"This makes it possible to decrease the dosage and duration of topical prednisolone acetate," the authors said.
Aylin Karalezli, MD, and colleagues at Baskent University School of Medicine in Ankara randomly assigned 60 patients undergoing uncomplicated phacoemulsification surgery to receive either 1 mg of Kenalog (triamcinolone acetonide, Bristol-Myers Squibb) in the anterior chamber or 1% prednisolone acetate topical eye drops after the procedure. Specifically, patients in the corticosteroid group received eye drops six times daily for 7 days and then four times daily for 15 days.
The investigators used slit lamp biomicroscopy to measure anterior chamber cells, anterior chamber flare and conjunctival hyperemia 1, 7 and 30 days postoperatively.
"Both treatments were equally effective in controlling postoperative inflammation following phacoemulsification," the authors said.
There were no statistically significant differences between the groups in terms of efficacy, safety and tolerance variables, and there were no serious adverse events, according to the study, published in the March issue of Acta Ophthalmologica.