December 10, 2010
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Inner limiting membrane detachment linked to foveal detachment in eyes with myopic macular retinoschisis

Am J Ophthalmol. 2010;150(6):863-870.

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Inner limiting membrane detachment in the superior or inferior peripheral macula strongly correlated with foveal retinal detachment in myopic eyes with macular retinoschisis, a study found.

"This feature may indicate strong tractional force on the ILM that are transmitted to the outer retina through the dense columnar structures, resulting in a foveal retinal detachment," the study authors said.

The retrospective study included 21 eyes of 19 patients with myopic macular retinoschisis. Mean patient age was 65.9 years.

High myopia was defined as axial length of 26 mm or greater; mean axial length was 29.7 mm.

Investigators analyzed fundus photographs and used enhanced spectral domain optical coherence tomography (SD-OCT) to compare anatomic features of eyes with and without foveal detachment.

Study results showed that retinoschisis in the outer retina was identified with splitting in the inner plexiform layer in 11 eyes (50%) and detachment of the ILM in 11 eyes (50%) in the superior and/or inferior peripheral macula. Both features were identified in nine eyes (42.9%).

Previous or progressive foveal detachment was identified in 13 eyes. ILM detachment developed in 10 eyes with foveal detachment (76.9%) and in one eye without foveal detachment (12.5%). The difference was statistically significant (P = .008).

Inner plexiform layer retinoschisis was detected in eight eyes with foveal detachment (61.5%) and in three eyes without foveal detachment (37.5%); the difference was statistically insignificant.