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Inflammation associated with ocular toxoplasmosis may differ around the world
Am J Ophthalmol. 2008;146(6):856-865.
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An individual's age, larger lesions on the retina and extramacular location of the retinal lesion may influence the degree of inflammation present in patients with ocular toxoplasmosis, although disease characteristics may vary in different areas of the world.
According to a review of records of 210 patients with toxoplasmic retinichorditis from seven clinical sites from around the world, presence of anterior chamber cells and flare correlated with vitreous inflammatory reactions. Elevated IOP was present in 30% of eyes and was associated with increased anterior chamber cells and elevated flare, as well as macular involvement.
"Results of this study also provide evidence that the severity of ocular disease in Brazil is greater than that in other areas of the world," the study said. However, "although statistical differences were identified between sites for [anterior chamber] cells, flare and vitreous haze, a consistent geographic pattern for differences could not be identified, and some may reflect methodologic differences in data collection between sites," the study said.