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Infectious keratitis after PRK should include gram-positive coverage

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EAST MEADOW, N.Y. — Infectious corneal ulceration is a serious potential complication of photorefractive keratectomy, and antibiotic treatment should be broad-spectrum and include gram-positive coverage, according to a study.

Eric Donnenfeld, MD, and colleagues here with Ophthalmic Consultants of Long Island reviewed the charts of 12 patients (13 eyes) that developed infectious keratitis after photorefractive keratectomy (PRK). Organisms cultured included two in the Staphylococcus family and two in the Streptococcus family. Prophylactic antibiotics used included tobramycin, polymyxin B-trimethoprim and ciprofloxacin. Final best corrected visual acuity ranged from 20/20 to 20/100.

The study is published in the April issue of Ophthalmology.