October 22, 2003
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Higher IOP associated with faster cupping progression

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A higher rate of progression of optic disc cupping was found in open-angle glaucoma patients with higher average intraocular pressures in a retrospective study.

Young H. Kwon, MD, PhD, and colleagues at the University of Iowa studied 51 eyes of 51 treated primary open-angle glaucoma patients with a minimum of 9-year longitudinal series of stereoscopic optic disc photographs. Mean age at baseline was 61.6 years. Mean follow-up was 14.3 years. The stereo photos were digitized, cup and disc margins were identified by an examiner and special software computed linear cup-to-disc ratios and peripapillary atrophy areas.

The initial linear cup-to-disc ratio was 0.64 and final linear cup-to-disc ratio was 0.73.

Three eyes had an increase in the area of peripapillary atrophy. A higher yearly average IOP was significantly associated with faster rate of progression of the linear cup-to-disc ratio.

The study is published in the Journal of Glaucoma.