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Higher blood levels of C-reactive protein an indicator for AMD

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Elevated levels of C-reactive protein in the blood may be an independent risk factor for age-related macular degeneration, according to a just-published study. C-reactive protein has already been identified as a systemic inflammatory marker associated with an increased risk for cardiovascular disease, the study authors noted.

Johanna Seddon, MD, ScM, at Massachusetts Eye and Ear Infirmary and colleagues enrolled 930 participants from the Age-Related Eye Disease Study into a case-controlled study to search for a link between C-reactive protein (CRP) levels and AMD. Of the participants, 222 had advanced AMD, 325 had intermediate AMD, 200 had mild maculopathy and 183 were without any maculopathy.

CRP levels were significantly higher in the participants with advanced AMD than those without symptoms of the disease. After adjusting for other risk factors, CRP levels were also significantly associated with intermediate AMD.

The study is published in the February issue of the Journal of American Medical Association.