This article is more than 5 years old. Information may no longer be current.

High ICG concentrations can impair retinal function, study finds

Add topic to email alerts

Receive an email when new articles are posted on

Please provide your email address to receive an email when new articles are posted on .

Subscribe

Added to email alerts

You've successfully added to your alerts. You will receive an email when new content is published.

Click Here to Manage Email Alerts

You've successfully added to your alerts. You will receive an email when new content is published.

Click Here to Manage Email Alerts

Back to Healio

We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com.

Back to Healio

Higher perioperative concentrations of indocyanine green during epiretinal membrane surgery can cause some postoperative functional impairment of the retina, a small study found.

"The lowest possible concentration of [indocyanine green] should be used intraoperatively to minimize potential retinal toxicity," the study authors said.

Timothy Y. Y. Lai, MMedSc, MRCSEd, of Hong Kong Eye Hospital, and colleagues reviewed outcomes of 13 patients randomly assigned to undergo epiretinal membrane surgery with either a 0.5 mg/mL or 1.25 mg/mL concentration of indocyanine green (ICG) to assist in peeling the internal limiting membrane.

Both groups showed significant improvements in visual acuity after surgery. At 3 months postop, however, patients treated with the 1.25 mg/mL concentration of ICG showed significant reductions in multifocal electroretinography N1 and P1 response amplitudes, according to the study authors.

The lower concentration group did not show any significant changes, the authors said.

The study is published in the January issue of Graefe's Archive for Clinical and Experimental Ophthalmology.