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High-density silicone oil initially disappointing for retinal detachment
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The anatomical success rate of a retinal detachment surgery with an endotamponade with Densiron 68 was initially disappointing, according to a study.
The authors note, however, that patients in the study had already undergone previous surgery with standard procedures, including silicone oil, and had failed.
Dirk Sandner and Katrin Engelmann at the University of Dresden in Germany analyzed data from 48 eyes of 48 patients between the ages of 27 and 82. All patients had re-detachments due to proliferative vitreoretinopathy and also had received a 3-month endotamponade of Densiron 68 (Geuder), a combination of high-density silicone oil and perfluorohexyloctane. The mean duration of the Densiron 68 endotamponade was 108 days, with a mean follow-up after removal of 102 days.
Of the patients, 22 showed stable retinal reattachment after the oil removal. Fourteen patients had developed re-detachment after removal, generally within the first month and in the upper circumference. In 11 patients, recurrent re-detachment appeared during Densiron 68 endotamponade. Of those eyes, one treatment was primarily unsuccessful.
Side effects included temporary inflammatory reaction, fibrin accumulation, sterile hypopyon, vitreous hemorrhage, elevated IOP, emulsification and chronic hypotony.
The study is published in the May issue of Graefe’s Archive for Clinical and Experimental Ophthalmology.