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Heparin-treated hydrophilic acrylic IOL works well in uveitic eyes

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LONDON — A heparin surface-modified hydrophilic acrylic lens has shown good biocompatibility and centration in uveitic eyes, according to a surgeon speaking here.

Claudette Abela-Formanek, MD, and colleagues at the Medical University of Vienna prospectively evaluated the biocompatibility of the three-piece, square-edged BioVue 3 IOL from Ophthalmic Innovations International in 30 patients with both cataract and uveitis. Dr. Abela-Formanek presented the findings at the European Society of Cataract and Refractive Surgery meeting.

At 1 year follow-up, eyes showed no significant difference in mean aqueous flare compared to preoperative levels, she said. Seven of the 30 IOLs had "mild cellular reaction," but it was not clinically significant, she noted.

Five patients required Nd:YAG laser capsulotomy — two with primary fibrosis and three with active cell proliferation, "comparable to hydrophobic lenses," she said. No eyes had uveitis flare-ups after cataract surgery, she added.

"The [heparin surface-modification] is responsible for the significantly reduced cellular reaction in eyes with ongoing chronic inflammation," Dr. Abela-Formanek said.