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Global-flash multifocal ERG detects early maculopathy deficits

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A multifocal electroretinogram using a global flash detected deficits in early age-related maculopathy sooner than conventional multifocal ERG, Australian researchers found.

Beatrix Feigl and colleagues at the Centre for Health Research in Queensland studied 20 healthy eyes and 12 age-matched eyes with age-related maculopathy (ARM), all of whom underwent conventional testing with multifocal ERG and extended tests with global-flash multifocal ERG.

“There was a significant reduction of the global-flash multifocal ERG direct response density in the early ARM group,” the authors said. “The superior retina showed longer implicit times than did the inferior retina for the direct response in the early ARM group.”

The authors suggest that retinal ischemia may play a role in producing functional impairment in ARM.

The study is published in the December issue of Investigative Ophthalmology & Visual Science.