This article is more than 5 years old. Information may no longer be current.

Glaucomatous optic nerve damage may be related to IOP, cerebrospinal fluid pressure

Add topic to email alerts

Receive an email when new articles are posted on

Please provide your email address to receive an email when new articles are posted on .

Subscribe

Added to email alerts

You've successfully added to your alerts. You will receive an email when new content is published.

Click Here to Manage Email Alerts

You've successfully added to your alerts. You will receive an email when new content is published.

Click Here to Manage Email Alerts

Back to Healio

We were unable to process your request. Please try again later. If you continue to have this issue please contact customerservice@slackinc.com.

Back to Healio

BOSTON — In open-angle glaucoma patients with normal IOP, cerebrospinal fluid pressure is abnormally low, leading to an abnormally high trans-lamina cribrosa pressure difference, according to a presenter here.

Ruojin Ren

Ruojin Ren, MD, studied 43 patients with open-angle glaucoma; 14 patients had normal IOP, and 29 patients had an elevated IOP. The control group consisted of 71 patients without glaucoma.

Lumbar cerebrospinal fluid pressure was significantly lower in the normal-IOP glaucoma group (9.5 ± 2.2 mm Hg) than in the high IOP group (11.7 ± 2.7 mm Hg) or the control group (12.9 ± 1.9 mm Hg), she said.

"The amount of glaucomatous optic nerve damage may be due to trans-lamina cribrosa pressure differences and inversely correlated with the cerebrospinal fluid pressure," she said at the World Glaucoma Congress.

Additionally, Dr. Ren said that in non-glaucomatous patients, cerebrospinal fluid pressure, blood pressure and IOP are significantly associated with each other.