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Glaucoma screening may benefit from optic nerve head topography

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Eyes with peripapillary myelinated nerve fibers showed a significantly smaller neuroretinal rim area and rim-to-disc area ratio compared with subjects' fellow eyes that had no myelination, a study found. "[The finding] should be taken into consideration when monitoring glaucoma suspects," the study authors said.

Mustafa Unal, MD, and colleagues performed topographic analyses of the optic nerve head in both eyes of 21 healthy subjects who averaged 28.3 years of age. All participants had unilateral peripapillary myelinated nerve fibers.

Investigators found that eyes with myelinated nerve fibers had a mean refractive error of –3.56 D, significantly higher compared with a mean refractive error of –0.98 D for subjects' fellow eyes (P < .05), according to the study.

Researchers observed no significant interocular differences in disc areas between eyes with myelinated nerve fibers and the fellow eyes. However, eyes with myelinated nerve fibers "were found to have significantly less 'neuroretinal rim area' and 'neuroretinal rim area-to-disc area ratio' than those eyes with no myelination (P < .05 for both)," the authors said.

The study is published in the September issue of Journal of Glaucoma.