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Genetic risk factors of AMD confirmed in European population

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PARIS — Polymorphisms of HTRA1 and PLEKHA1 genes are risk factors for exudative age-related macular degeneration in the European population, according to a study carried out at university eye clinics in Créteil, Paris and Lille.

The study, presented at the meeting of the French Society of Ophthalmology, examined the DNA of 277 patients affected by exudative AMD and 173 age-matched controls. In the AMD group, the presence of the allele T of the HTRA1 gene was double that in the control group (0.50 vs 0.23). Also, the presence of the allele A of the PLEKHA1 gene was significantly higher in the AMD group than in the control group (0.63 vs. 0.48).

"These results might have important implications in finding new treatment strategies for AMD," N. Leveziel, MD, said.

The association of these genetic risk factors with other clinical types of AMD may help establish a genotype-phenotype correlation in AMD.