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Gatifloxacin may play prophylactic role in endophthalmitis

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Eyes treated with gatifloxacin showed “significantly less inflammation, infection and culture-positive endophthalmitis” than eyes not treated with the drug, according to a rabbit study.

Luis E. Fernández de Castro and colleagues at the Magill Research Center for Vision Correction randomized 40 rabbits to one drop of 0.3% gatifloxacin in one eye every 14 minutes for one hour, or one drop of balanced salt solution at the same intervals. Each rabbit was then injected with a clinical isolate of Staphylococcus aureus. After injection, treatment resumed with drops being administered immediately postinjection and at 6, 12, 18 and 24 hours.

The median clinical scores for the gatifloxacin group were significantly lower than the control group. Bacterial recovery was significantly higher in the control group in both the aqueous and vitreous humor.

“In our study, prophylactic treatment with 0.3% gatifloxacin proved to be a valuable adjunct for the prevention of S. aureus endophthalmitis,” they said. The authors recommend further research into the prophylactic role of gatifloxacin.

The study is published in the Journal of Ocular Pharmacology and Therapeutics.