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Fibrin sealant yields low complication rate for Müller's muscle-conjunctiva resection
Ophthal Plast Reconstr Surg. 2009;25(2):99-102.
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Fibrin sealant and sutures resulted in comparable eye lid positioning after Müller's muscle-conjunctiva resection ptosis repair. Fibrin was associated with fewer postop complications.
"Use of Tisseel (fibrin sealant, Baxter AG) showed fewer postoperative complications and was associated with fewer subsequent surgical procedures," the study authors said.
The retrospective chart review included 211 eye lids of 114 patients who underwent Müller's muscle-conjunctiva resection with Tisseel or suture. Records included 17 unilateral cases and 97 bilateral cases. Sutures were used in 45 eye lids of 31 patients; Tisseel was used in 166 eye lids of 83 patients.
In the suture group, mean preoperative marginal reflex distance (MRD1) was 1.2 mm; postoperative MRD1 was 3 mm.
In the Tisseel group, mean preoperative MRD1 was 1.2 mm and the postoperative MRD1 was 3 mm. Variations in preoperative and postoperative MRD1 values, differences and postoperative symmetry within 0.05 mm were not statistically significant.
Complications in the suture group included moderate to acute pain, suture granuloma, corneal abrasion, loose sutures and persistent keratopathy. No evidence of keratopathy was attributed to Tisseel.
Four patients in the suture group underwent suture granuloma removal, suture removal or levator resection. Three patients in the Tisseel group had subsequent levator resection, the authors said.