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Femtosecond laser-assisted LASIK, steroids spur keratocyte activation

J Refract Surg. 2008;24:847-849.

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Femtosecond laser-assisted LASIK with attenuated steroids significantly promoted keratocyte activation.

A study included 30 eyes of 30 patients who underwent LASIK with the IntraLase FS60 femtosecond laser (Advanced Medical Optics) used for flap creation.

After surgery, patients used one ocular steroid, Econopred Plus (Alcon), hourly for 1 day and four times daily for 7 days. Patients underwent clinical examination and confocal microscopy 3 months after surgery.

Slit lamp examination showed trace haze at the flap interface in two corneas, and confocal microscopy showed significant keratocyte activation in both of those corneas. Results showed no clinically significant flap interface haze, and keratocyte activation was found at the flap interface in 10 eyes.

Measured interface reflectivity was 328.8 confocal backscatter units in eyes with activated keratocytes and 88.9 units in the remaining 19 eyes.

"With attenuated steroids, keratocyte activation was found in a significant number of eyes, although interface haze was subclinical," the study authors said. "A higher steroid dosage might therefore be indicated."