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Enhanced depth imaging mode of OCT detects differences by glaucoma type
Ophthalmology. 2012:119(1);10-20.
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In normal tension glaucoma and primary open-angle glaucoma, enhanced depth imaging mode of optical coherence tomography detected differences in the thickness of lamina cribrosa, according to study results.
"Our study showed that eyes with [normal tension glaucoma] with disc hemorrhage had a thinner lamina," the researchers wrote.
Objectives for conducting this cross-sectional, case-control study were twofold: to compare laminar thicknesses of various glaucoma types with or without disc hemorrhage in a similar state of visual field loss, and to confirm the advantages of the enhanced depth imaging mode vs. the standard mode of the Heidelberg Spectralis spectral domain OCT for imaging of the lamina cribrosa.
Between June 2010 and August 2010, the researchers recruited 137 Korean adults with glaucoma and 49 healthy participants as controls. They used the standard and enhanced depth imaging modes of the Spectralis OCT to obtain optic nerve head B-scans, and laminar thickness was measured.
Results showed that enhanced depth imaging provided better intraobserver, interobserver, intravisit and intervisit reproducibility than standard imaging.
"Laminar thickness in mid-superior, central and mid-inferior regions was thinner in the [primary open-angle glaucoma] and [normal tension glaucoma] groups than in the normal control group," they wrote. "The mid-superior, central and mid-inferior regions
of the lamina were also significantly thinner in patients with [normal tension glaucoma] and disc hemorrhage than in those with [normal tension glaucoma] but no disc hemorrhage."