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Early eye development not altered by in vitro fertilization, study shows

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In vitro fertilization does not affect early ocular growth, IOP, corneal curvature changes or retinal vascularization in premature infants, according to an Israeli study.

Ruth Axer-Siegel and colleagues at Tel Aviv University assessed biometric and keratometric values, IOP and retinal vascular status of 133 premature infants to determine the possible effect of in vitro fertilization compared with natural conception in early ocular development. Of the 133 premature infants, 62 were conceived in vitro. Postconception age at examination was 28 to 46 weeks.

Lens thickness was slightly different between the two groups. Retinal vascularization correlated with postconception age as well. No correlation was found between IOP and corrected age or weight at examination. A two-way analysis of variance found no difference in any of the biometric or keratometric parameters.

The study is published in the April issue of Investigative Ophthalmology & Visual Science.