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Dye-plus-laser treatment shows potential for corneal incision sealing
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A treatment that combines dye treatment and laser irradiation showed promise as a method of corneal incision closure in an animal eye study.
Cinthia E. Proaño and colleagues at the Schepens Eye Research Institute evaluated the use of photochemical keratodesmos (PKD) in a study in rabbit eyes. The researchers created 3.5-mm incisions in rabbit corneas and stained them with rose bengal dye. This was followed by exposure to 514-nm laser radiation at several fluences. The IOP at which leakage occurred during infusion of saline into each anterior chamber was determined.
IOPs of more than 500 mm Hg were tolerated in eyes treated with the highest laser fluences, compared to 40 mm Hg in control eyes. No reduction in the IOP at which leakage occurred was observed up to 14 days after surgery. Corneal melting in PKD-treated or control eyes was not observed in the 10-week healing study. Neovascularization, which peaked at 4 weeks but resolved by 8 weeks, was detected around the incision in both PKD-treated and control eyes.
The study is published in the July issue of Investigative Ophthalmology & Visual Science.