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DSAEK spurs increased ocular hypertension and diminished IOP control
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SAN FRANCISCO — Ocular hypertension increased after Descemet's stripping automated endothelial keratoplasty, but the increase was lower than that reported after penetrating keratoplasty.
 Nickolas P. Katsoulakis |
"While there appears to be an increased incidence of elevated IOP postoperatively after DSAEK, it appears to be less than historically reported after penetrating keratoplasty. Long-term response after DSAEK requires further study," Nickolas P. Katsoulakis, MD, said at the American Society of Cataract and Refractive Surgery meeting here.
The retrospective study included 127 eyes that underwent DSAEK. Investigators assessed preoperative and postoperative IOP, changes in glaucoma medication use and need for subsequent interventions such as laser trabeculoplasty and/or glaucoma surgery. Patients were followed-up for at least 3 months postoperatively.
Mean preop IOP was 15 mm Hg ± 5 mm Hg. At 3 months postop, mean IOP was 17 mm Hg ± 6 mm Hg. Postop IOP was at least 30% higher than preop pressure in 27 eyes (21%).
Thirty-two eyes had previously diagnosed glaucoma and were being administered eye drops to control IOP. Of those 32 eyes, four required additional medications to control IOP. Corticosteroids may contribute to elevated IOP but other factors may be important contributors, Dr. Katsoulakis said.