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Dorzolamide shows higher thickness rate increases in eyes with cornea guttata

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VIENNA, Austria — Applying dorzolamide for 1 day slightly increases the central corneal thickness in patients with cornea guttata, according to a study. The increase, although slight, was statistically significant, researchers noted.

Matthias G. Wirtitsch, MD, and colleagues at the University of Vienna randomized 20 patients with cornea guttata and eight healthy controls to receive 2% dorzolamide hydrochloride, 0.9% saline solution or a solution identical to the carrier substance of dorzolamide (carrier placebo). All drugs were administered four times daily for 1 day. Partial coherence interferometry was used to determine the central corneal thickness at baseline and 24 hours after treatment.

Within 24 hours, eyes treated with dorzolamide showed a mean thickening in central corneal thickness of 12 µm. Eyes treated with saline placebo showed a mean thickening of 0.6 µm, and eyes treated with carrier placebo showed a mean thickening of 1.3 µm.

The study is published in the May issue of Archives of Ophthalmology.