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Diclofenac effective in vernal keratoconjunctivitis
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ROME — Preservative-free diclofenac sodium 0.1% is safe and effective in controlling the signs and symptoms of vernal keratoconjunctivitis in prolonged treatment, according to a study.
Alessandro Lambiase and colleagues here with the University studied 22 patients with vernal keratoconjunctivitis who were treated with preservative-free diclofenac sodium eye drops. Patients used the eye drops four times daily in both eyes for 120 days. Signs, such as papillae, hyperemia and corneal lesions, and symptoms, such as itching, redness and photophobia, of the ocular surface were graded and statistically evaluated at baseline and follow-up.
At the last follow-up visit, 40% of the patients showed a significant improvement in their symptoms from baseline (P < .001). Conjunctival redness, itching and photophobia were all significantly decreased from baseline as well (P < .001). No significant differences were observed in the corneal lesions or papillary size.
The study is published in the February issue of Graefe’s Archive for Clinical and Experimental Ophthalmology.