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Diagnostic accuracy affected by disease progression

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FT. LAUDERDALE, Fla. — Atypical retardation patterns, such as decreasing typical scan scores, may affect the diagnostic accuracy of some machines, according to one speaker.

Christopher Bowd, PhD, imaged 233 eyes with glaucoma (153 patients) and compared results with 104 healthy eyes of 71 participants. All enrollees underwent GDx Variable Corneal Compensation (VCC) imaging. Dr. Bowd presented his results here at the International Society for Imaging in the Eye.

“With GDx the macula is scanned to determine the individual, and it gives a properly compensated image for each individual eye,” Dr. Bowd said. “Studies show VCC has better diagnostic accuracy than with fixed corneal compensations.”

The presence of an atypical scan with low typical scan score values decreased the diagnostic accuracy of the VCC, Dr. Bowd said. The diagnostic accuracy “increased with increasing disease severity,” he said.

Dr. Bowd added that recent improvements to the GDx software include enhanced corneal compensation, which have likely successfully addressed the issue of atypical scans.