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Deep sclerectomy, MMC ineffective in West African population

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Deep sclerectomy coupled with intraoperative application of mitomycin C did not significantly lower IOP in a West African population, according to a study.

Nitin Anand and colleagues performed deep sclerectomy on 39 Nigerian patients with primary open-angle glaucoma who had uncontrolled IOP and no previous ophthalmic surgery. MMC was applied in 18 of the patients by placing two to four collagen sponges dipped in 0.25 mg/mL of MMC in the subconjunctival space behind the scleral flap for 2 minutes. Mean follow-up was 16.4 months.

The probability of maintaining IOP under 18 mm HG with or without additional medications at 1 year was 70% for the group that did not receive MMC and 79% for those who did, and fell to 35% for the non-MMC group and 38% for the MMC group by month 18.

An IOP of less than 18 mm Hg without additional medication was maintained in 65% of those without MMC and 73% of those with MMC at the 1-year follow-up, which fell to 24% in the non-MMC group and 13% in the MMC group by month 18.

This study is published in British Journal of Ophthalmology.