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Cross-linking with riboflavin and UV light may stop keratoconus progression

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BARCELONA — Corneal cross-linking with riboflavin and UV light is a safe procedure that has shown to stop the progression of keratoconus, according to 2-year study results presented here. Additionally, patients with a previous progression of keratoconus had reductions in corneal curvature.

"Keratoconus was shown to be stable and showed regression over a 2-year period. We anticipate this may happen further after this period," Mirki Kjankov, MD, said at the European Society of Cataract and Refractive Surgeons meeting.

In the study, 34 eyes of 22 patients had progressive keratoconus in the previous 6 months. The epithelium was removed mechanically and the cornea was soaked with riboflavin for 15 minutes and then irradiated with UV light for 30 minutes.

The preoperative best corrected visual acuity was 0.41 ± 0.18. Postoperative BCVA increased after 3 months to 0.6 ± 0.29, and increased more at 1 and 2 years. The progression of keratoconus stopped in all patients, he said. No eye lost any line of BCVA, and one-third of the eyes gained two or more lines of BCVA.