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Corticosteroids seem to diminish CME risk in uveitic eyes before cataract surgery
Am J Ophthalmol. 2009;148(1):128-135.
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Eyes with well-controlled uveitis had postop outcomes similar to control eyes up to 3 months after cataract surgery, a study showed.
"Use of perioperative oral corticosteroids and control of uveitis for more than 3 months before surgery seemed to decrease the risk of postoperative [cystoid macular edema] among uveitic eyes in this study," the authors said.
The prospective cohort study included 41 eyes with uveitis and 52 control eyes without uveitis. Investigators used optical coherence tomography to determine the presence of cystoid macular edema (CME). The primary outcome measure was the incidence of CME at 1 and 3 months postop.
Study data showed that uveitic and non-uveitic eyes gained about three lines of visual acuity. The incidence of CME among uveitic eyes was 12% at 1 month and 8% at 3 months; the incidence of CME among control eyes was 4% at 1 month and 0% at 3 months.
Administration of postop oral corticosteroids reduced the postop risk of CME in uveitic eyes by a factor of seven. The risk of CME was significantly higher in uveitic eyes with active inflammation less than 3 months before surgery than in eyes without inflammation.
Data also showed a significant correlation between CME and poor vision (P = .01), the authors said.