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Correlations found between corneal hysteresis, keratoconus in glaucoma patients and suspects
Cornea. 2010;29(9):955-970.
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Low corneal hysteresis measurements correlated with the severity of keratoconus in patients with glaucoma or suspected glaucoma, a study found.
The prospective study included 29 eyes of 20 patients with keratoconus and pellucid marginal corneal degeneration, with glaucoma or suspected glaucoma, and 61 eyes of 40 age-matched control patients with keratoconus and pellucid marginal corneal degeneration, without glaucoma.
The investigators performed corneal topography, pachymetry, IOP, A-scan, visual field and optic disc measurements. The Ocular Response Analyzer (Reichert) was used to measure corneal hysteresis (CH) and corneal resistance factor (CRF).
Study results showed a mean CH of 8.2 in the study group and 8.3 in the control group. Mean CRF was 7.3 in the study group and 6.9 in the comparator group. Both measurements were low; between-group differences were not significant.
The investigators found a significant correlation between CH and maximum corneal curvature (P < .002) and a significant positive correlation between CH and central corneal thickness (P < .003).
The study group had a mean cup-to-disc ratio of 0.54, and the control group had a mean cup-to-disc ratio of 0.38 (P = .003).
In addition, visual fields showed suspected glaucoma in 11 study group eyes (33.9%) and eight control group eyes (13.3%). The between-group variance was statistically significant (P = .019).