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Correlation found between IOP and conjunctival hyperemia due to prostaglandin
J Glaucoma. 2010;doi:10.1097/IJG.0b013e3181d26024.
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Latanoprost-induced conjunctival hyperemia has a significant relationship with a change in IOP at 6 months, a study found.
One hundred fourteen patients with open-angle glaucoma or ocular hypertension who were beginning latanoprost therapy were enrolled in the study. Patients were instructed to administer latanoprost every morning and were reviewed at 2 days and 1, 4, 8, 12 and 24 weeks after start-up, the study authors said.
At 6 months, mean IOP decreased from 22.5 mm Hg to 16.5 mm Hg, and mean conjunctival hyperemia grade 2 days after latanoprost administration increased from 0.32 to 1.74. Mean change in IOP was –1.7 mm Hg in patients with no hyperemia grade change, –5.2 mm Hg in patients with a hyperemia grade change of 1, –7.3 mm Hg in patients with a change of 2 and –10.8 mm Hg in patients with a change of 3 or 4, the study said.
"The reason for the correlation between the change in hyperemia and intraocular pressure is not known exactly. One reason could be that the mechanism of both the intraocular pressure-lowering effect and the localized vessel dilation may be mediated by the FP receptor, although this reasoning is speculative," the study authors said.
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